Characterization of a reproducible rat model of hepatic veno–occlusive disease
LD DeLeve, RS McCuskey, X Wang, L Hu… - Hepatology, 1999 - journals.lww.com
Lack of a reproducible animal model has hampered progress in understanding hepatic veno–
occlusive disease (HVOD). This article characterizes a reproducible model of HVOD. Rats
gavaged with monocrotaline, 160 mg/kg, were killed between days 1 and 10. Sections were
evaluated by light microscopy with a standardized scoring system, by immunoperoxidase
staining with ED–1 (monocytes, macrophages) and ED–2 (Kupffer cells) antibodies, and by
transmission (TEM) and scanning electron microscopy (SEM). On days 1 and 2, the earliest …
occlusive disease (HVOD). This article characterizes a reproducible model of HVOD. Rats
gavaged with monocrotaline, 160 mg/kg, were killed between days 1 and 10. Sections were
evaluated by light microscopy with a standardized scoring system, by immunoperoxidase
staining with ED–1 (monocytes, macrophages) and ED–2 (Kupffer cells) antibodies, and by
transmission (TEM) and scanning electron microscopy (SEM). On days 1 and 2, the earliest …