[HTML][HTML] Propagation of tau misfolding from the outside to the inside of a cell
B Frost, RL Jacks, MI Diamond - Journal of biological chemistry, 2009 - ASBMB
Tauopathies are neurodegenerative diseases characterized by aggregation of the
microtubule-associated protein Tau in neurons and glia. Although Tau is normally
considered an intracellular protein, Tau aggregates are observed in the extracellular space,
and Tau peptide is readily detected in the cerebrospinal fluid of patients. Tau aggregation
occurs in many diseases, including Alzheimer disease and frontotemporal dementia. Tau
pathology begins in discrete, disease-specific regions but eventually involves much larger …
microtubule-associated protein Tau in neurons and glia. Although Tau is normally
considered an intracellular protein, Tau aggregates are observed in the extracellular space,
and Tau peptide is readily detected in the cerebrospinal fluid of patients. Tau aggregation
occurs in many diseases, including Alzheimer disease and frontotemporal dementia. Tau
pathology begins in discrete, disease-specific regions but eventually involves much larger …