Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
F Jiang, CJ Parsons, B Stefanovic - Journal of hepatology, 2006 - Elsevier
BACKGROUND/AIMS: Liver fibrosis is characterized by accumulation of extracellular matrix
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular
mechanisms of HSCs activation a comprehensive comparison of gene expression between
quiescent and activated HSCs is needed. METHODS: Using DNA microarrays we compared
expression of 31,100 genes between quiescent rat HSCs and culture activated rat HSCs.
Expression of the components of Wnt signaling was analyzed in HSCs and fibrotic livers by …
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular
mechanisms of HSCs activation a comprehensive comparison of gene expression between
quiescent and activated HSCs is needed. METHODS: Using DNA microarrays we compared
expression of 31,100 genes between quiescent rat HSCs and culture activated rat HSCs.
Expression of the components of Wnt signaling was analyzed in HSCs and fibrotic livers by …