Continuous administration of poloxamer 188 reduces overload-induced muscular atrophy in dysferlin-deficient SJL mice
N Suzuki, T Akiyama, T Takahashi, H Komuro… - Neuroscience …, 2012 - Elsevier
Dysferlin-deficient SJL mice are commonly used to study dysferlinopathy. We demonstrated
that poloxamer 188 (P188), a membrane sealant, is effective in reducing the loss of muscle
mass in SJL mice when administered using an osmotic pump for 6 weeks. We did not
observe significant changes over a 2-week administration period, suggesting that longthier
observation is necessary to determine the effectiveness of P188. We also examined
exercise endurance in P188-administered SJL mice using a rolling cage. Phosphorylated …
that poloxamer 188 (P188), a membrane sealant, is effective in reducing the loss of muscle
mass in SJL mice when administered using an osmotic pump for 6 weeks. We did not
observe significant changes over a 2-week administration period, suggesting that longthier
observation is necessary to determine the effectiveness of P188. We also examined
exercise endurance in P188-administered SJL mice using a rolling cage. Phosphorylated …