Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants
DA Stern, J Riedler, D Nowak… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: IgE synthesis by human B cells results from allergen-dependent, TH2-
mediated isotype switching. Exposure to a farming environment protects against IgE
responses. OBJECTIVE: We reconstructed allergen-dependent switching patterns in vivo to
identify the level or levels at which farm exposure acts to protect against atopy. METHODS:
Serum IgG1 to IgG4 and IgE to grass (rPhl p 1 and rPhl p 5), cat (rFel d 1), and mite (rDer p
2) were assessed by means of ELISA in the Allergy and Endotoxin study population (812 …
mediated isotype switching. Exposure to a farming environment protects against IgE
responses. OBJECTIVE: We reconstructed allergen-dependent switching patterns in vivo to
identify the level or levels at which farm exposure acts to protect against atopy. METHODS:
Serum IgG1 to IgG4 and IgE to grass (rPhl p 1 and rPhl p 5), cat (rFel d 1), and mite (rDer p
2) were assessed by means of ELISA in the Allergy and Endotoxin study population (812 …