Intermediate filaments represent the most abundant cytoskeletal element in mature neurons.
Mutations and/or accumulations of neuronal intermediate filament proteins are frequently
observed in several human neurodegenerative disorders. Although it is now admitted that
disorganization of the intermediate filament network may be directly involved in
neurodegeneration, certain types of perikaryal intermediate filament aggregates confer
protection in motor neuron disease. The use of various mouse models provided a better …