[HTML][HTML] The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome
E Berezutskaya, S Bagchi - Journal of Biological Chemistry, 1997 - ASBMB
Human papillomaviruses (HPV) have been etiologically linked to human cervical cancer.
More than 90% of cervical cancer tissues express two HPV-encoded oncoproteins E6 and
E7. Both E6 and E7 proteins possess transformation activity. and together they cooperate to
transform primary human keratinocytes, fibroblasts. and epithelial cells. The transforming
activity of E7 is associated with its ability to bind the retinoblastoma tumor suppressor protein
(Rb). However, the carboxyl-terminal mutants of E7 are also defective for transformation …
More than 90% of cervical cancer tissues express two HPV-encoded oncoproteins E6 and
E7. Both E6 and E7 proteins possess transformation activity. and together they cooperate to
transform primary human keratinocytes, fibroblasts. and epithelial cells. The transforming
activity of E7 is associated with its ability to bind the retinoblastoma tumor suppressor protein
(Rb). However, the carboxyl-terminal mutants of E7 are also defective for transformation …