Cullin RING ligases (CRLs), the most prolific class of ubiquitin ligase enzymes, are
multimeric complexes that regulate a wide range of cellular processes. CRL activity is
regulated by CAND1 (Cullin-associated Nedd8-dissociated protein 1), an inhibitor that
promotes the dissociation of substrate receptor components from the CRL. We demonstrate
here that COMMD1 (copper metabolism MURR1 domain-containing 1), a factor previously
found to promote ubiquitination of various substrates, regulates CRL activation by …