[HTML][HTML] A Mycobacterium ulcerans toxin, mycolactone, induces apoptosis in primary human keratinocytes and in HaCaT cells
C Bozzo, R Tiberio, F Graziola, G Pertusi, G Valente… - Microbes and …, 2010 - Elsevier
The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) depends on cytotoxic effect of its
exotoxin mycolactone. Since epidermis represents a barrier against infectious agents and
balanced apoptosis is essential in epidermal homeostasis, we explored if mycolactone A/B
induces apoptosis on two human keratinocyte populations, stem cells (KSC) and transit
amplifying cells (TAC), and on human keratinocyte line, HaCaT. Treatment of TAC with 1
and 10 ng/ml mycolactone-induced 60 and 90% apoptosis. KSC were more resistant than …
exotoxin mycolactone. Since epidermis represents a barrier against infectious agents and
balanced apoptosis is essential in epidermal homeostasis, we explored if mycolactone A/B
induces apoptosis on two human keratinocyte populations, stem cells (KSC) and transit
amplifying cells (TAC), and on human keratinocyte line, HaCaT. Treatment of TAC with 1
and 10 ng/ml mycolactone-induced 60 and 90% apoptosis. KSC were more resistant than …