[HTML][HTML] Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in glut2-null hepatocytes: Further evidence for …
R Burcelin, M del Carmen Muñoz, MT Guillam… - Journal of Biological …, 2000 - ASBMB
We investigated the impact of GLUT2 gene inactivation on the regulation of hepatic glucose
metabolism during the fed to fast transition. In control and GLUT2-null mice, fasting was
accompanied by a∼ 10-fold increase in plasma glucagon to insulin ratio, a similar activation
of liver glycogen phosphorylase and inhibition of glycogen synthase and the same elevation
in phosphoenolpyruvate carboxykinase and glucose-6-phosphatase mRNAs. In GLUT2-null
mice, mobilization of glycogen stores was, however, strongly impaired. This was correlated …
metabolism during the fed to fast transition. In control and GLUT2-null mice, fasting was
accompanied by a∼ 10-fold increase in plasma glucagon to insulin ratio, a similar activation
of liver glycogen phosphorylase and inhibition of glycogen synthase and the same elevation
in phosphoenolpyruvate carboxykinase and glucose-6-phosphatase mRNAs. In GLUT2-null
mice, mobilization of glycogen stores was, however, strongly impaired. This was correlated …