[HTML][HTML] Glucagon-like peptide-1 increases β-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression
M Cornu, H Modi, D Kawamori, RN Kulkarni… - Journal of Biological …, 2010 - ASBMB
Glucagon-like peptide-1 (GLP-1) protects β-cells against apoptosis, increases their glucose
competence, and induces their proliferation. We previously demonstrated that the anti-
apoptotic effect was mediated by an increase in insulin-like growth factor-1 receptor (IGF-
1R) expression and signaling, which was dependent on autocrine secretion of insulin-like
growth factor 2 (IGF-2). Here, we further investigated how GLP-1 induces IGF-1R expression
and whether the IGF-2/IGF-1R autocrine loop is also involved in mediating GLP-1-increase …
competence, and induces their proliferation. We previously demonstrated that the anti-
apoptotic effect was mediated by an increase in insulin-like growth factor-1 receptor (IGF-
1R) expression and signaling, which was dependent on autocrine secretion of insulin-like
growth factor 2 (IGF-2). Here, we further investigated how GLP-1 induces IGF-1R expression
and whether the IGF-2/IGF-1R autocrine loop is also involved in mediating GLP-1-increase …