IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen
JD Ooi, RKS Phoon, SR Holdsworth… - Journal of the American …, 2009 - journals.lww.com
The autoantigen in Goodpasture disease is the noncollagenous domain of α3 type IV
collagen [α3 (IV) NC1]. We previously demonstrated that IL-12p40−/− mice are protected
from experimental autoimmune anti–glomerular basement membrane (anti-GBM)
glomerulonephritis, seemingly defining a role for IL-12 in this disease; however, the recent
identification of IL-23, a heterodimer composed of IL-12p40 and IL-23p19 subunits, raises
the possibility that IL-23, rather than IL-12, may modulate this disease instead. We …
collagen [α3 (IV) NC1]. We previously demonstrated that IL-12p40−/− mice are protected
from experimental autoimmune anti–glomerular basement membrane (anti-GBM)
glomerulonephritis, seemingly defining a role for IL-12 in this disease; however, the recent
identification of IL-23, a heterodimer composed of IL-12p40 and IL-23p19 subunits, raises
the possibility that IL-23, rather than IL-12, may modulate this disease instead. We …