ACP Broadsheet No 143: January 1994. Detection of autoantibodies to neutrophil cytoplasmic antigens.

RJ Lock - Journal of clinical pathology, 1994 - ncbi.nlm.nih.gov
RJ Lock
Journal of clinical pathology, 1994ncbi.nlm.nih.gov
Clinical correlations Until the discovery of this group of antibodies, there was no specific
laboratory method for the investigation of systemic necrotising vasculitis, other than
histological examination of biopsy material. In 1982 Davies et al described ANCA in a small
group of patients with a necrotising glomerulonephritis. 4 In 1985 this cytoplasmic staining
pattern (classic, c-ANCA) was recognised as
Clinical correlations Until the discovery of this group of antibodies, there was no specific laboratory method for the investigation of systemic necrotising vasculitis, other than histological examination of biopsy material. In 1982 Davies et al described ANCA in a small group of patients with a necrotising glomerulonephritis. 4 In 1985 this cytoplasmic staining pattern (classic, c-ANCA) was recognised as
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