The definition and epidemiology of non-transfusion-dependent thalassemia
DJ Weatherall - Blood reviews, 2012 - Elsevier
Inherited hemoglobin-related disorders, which include the structural variants (hemoglobin S,
C, and E) and the alpha (α)-and beta (β)-thalassemias, affect more than 300,000 children
annually, particularly in malaria-endemic regions stretching from sub-Saharan Africa and the
Mediterranean to Southeast Asia. Screening for carriers of these traits is important to provide
prenatal genetic counseling and to accurately estimate the true prevalence and public
health burden of these disorders. The clinical course of thalassemias, which affect nearly …
C, and E) and the alpha (α)-and beta (β)-thalassemias, affect more than 300,000 children
annually, particularly in malaria-endemic regions stretching from sub-Saharan Africa and the
Mediterranean to Southeast Asia. Screening for carriers of these traits is important to provide
prenatal genetic counseling and to accurately estimate the true prevalence and public
health burden of these disorders. The clinical course of thalassemias, which affect nearly …