DBA/1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest
CL Faingold, M Randall, S Tupal - Epilepsy & Behavior, 2010 - Elsevier
One proposed cause of sudden unexpected death in epilepsy (SUDEP) in patients is
generalized convulsive seizures with respiratory malfunction. We evaluated DBA/1 mice as
a chronic SUDEP model. In DBA/1 mice, audiogenic seizures induced by acoustic
stimulation resulted in generalized convulsive seizures followed by respiratory arrest from
postnatal day (PND) 21 to 100. The incidence of respiratory arrest susceptibility increased,
reaching∼ 90–100% by three to seven daily seizures when testing began on PND 21–30 …
generalized convulsive seizures with respiratory malfunction. We evaluated DBA/1 mice as
a chronic SUDEP model. In DBA/1 mice, audiogenic seizures induced by acoustic
stimulation resulted in generalized convulsive seizures followed by respiratory arrest from
postnatal day (PND) 21 to 100. The incidence of respiratory arrest susceptibility increased,
reaching∼ 90–100% by three to seven daily seizures when testing began on PND 21–30 …