Visualisation by electron microscopy of the unique part of the cytoplasmic domain of a desmoglein, a cadherin‐like protein of the desmosome type of cell junction

AJ Rutman, RS Buxton, IDJ Burdett - FEBS letters, 1994 - Wiley Online Library
AJ Rutman, RS Buxton, IDJ Burdett
FEBS letters, 1994Wiley Online Library
Part of the cytoplasmic domain of a human desmoglein, Dsgl, a cadherin‐like protein found
in desmosomes of epithelial cells, has been visualised by electron microscopy. The cloned
fragment contains five repeats of a 29±4 residue sequence unique to desmogleins, followed
by a glycine‐rich region. In rotary shadowed preparations the molecule consists of a
globular head attached to a thin tail, the latter perhaps corresponding to the glycine‐rich
region. This portion of the molecule is thought to span the width of the inner dense plaque …
Part of the cytoplasmic domain of a human desmoglein, Dsgl, a cadherin‐like protein found in desmosomes of epithelial cells, has been visualised by electron microscopy. The cloned fragment contains five repeats of a 29 ± 4 residue sequence unique to desmogleins, followed by a glycine‐rich region. In rotary shadowed preparations the molecule consists of a globular head attached to a thin tail, the latter perhaps corresponding to the glycine‐rich region. This portion of the molecule is thought to span the width of the inner dense plaque. The structure and dimensions concur well to the configuration deduced from the protein sequence.
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