Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis
H Takahashi, M Ibe, S Nakamura… - Journal of …, 2002 - Elsevier
Psoriatic skin shows markedly increased keratinocyte proliferation and altered differentiation
with various abnormal signalling pathways. In the present study, we investigated the
expression of mitogen-activated protein kinases in psoriatic skin. Immunohistochemical
study showed increased extracellular regulated kinase (ERK) and c-Jun N-terminal kinase
(JNK) expression in the nuclei of involved epidermis. Western blot analyses confirmed the
increased active phospho-ERK and phospho-JNK expression in the involved epidermis. In …
with various abnormal signalling pathways. In the present study, we investigated the
expression of mitogen-activated protein kinases in psoriatic skin. Immunohistochemical
study showed increased extracellular regulated kinase (ERK) and c-Jun N-terminal kinase
(JNK) expression in the nuclei of involved epidermis. Western blot analyses confirmed the
increased active phospho-ERK and phospho-JNK expression in the involved epidermis. In …