Endogenous opioid-mediated antinociception in cholestatic mice is peripherally, not centrally, mediated
L Nelson, N Vergnolle, C D'Mello, K Chapman, T Le… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: Cholestasis is associated with naloxone reversible antinociception
and opiate receptor antagonists are used clinically to treat pruritus. Pain and pruritus are
closely interrelated and opioids modulate both sensations. Therefore, we undertook a series
of experiments to characterize opioid-mediated antinociception in cholestasis and determine
if it occurs inside or outside the CNS. METHODS: Antinociception scores to both thermal and
mechanical stimuli were determined in mice with cholestasis due to bile duct resection vs …
and opiate receptor antagonists are used clinically to treat pruritus. Pain and pruritus are
closely interrelated and opioids modulate both sensations. Therefore, we undertook a series
of experiments to characterize opioid-mediated antinociception in cholestasis and determine
if it occurs inside or outside the CNS. METHODS: Antinociception scores to both thermal and
mechanical stimuli were determined in mice with cholestasis due to bile duct resection vs …