Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase
C Fekete, RM Lechan - Frontiers in neuroendocrinology, 2007 - Elsevier
Hypophysiotropic thyrotropin-releasing hormone (TRH): synthesizing neurons reside in the
hypothalamic paraventricular nucleus (PVN) and are the central regulators of the
hypothalamic-pituitary-thyroid (HPT) axis. TRH synthesis and release from these neurons
are primarily under negative feedback regulation by thyroid hormone. Under certain
conditions such as cold exposure and fasting, however, inputs from neurons in the
brainstem and hypothalamic arcuate and dorsomedial nuclei alter the set point for negative …
hypothalamic paraventricular nucleus (PVN) and are the central regulators of the
hypothalamic-pituitary-thyroid (HPT) axis. TRH synthesis and release from these neurons
are primarily under negative feedback regulation by thyroid hormone. Under certain
conditions such as cold exposure and fasting, however, inputs from neurons in the
brainstem and hypothalamic arcuate and dorsomedial nuclei alter the set point for negative …