[HTML][HTML] ATP-binding cassette transporter A1 expression disrupts raft membrane microdomains through its ATPase-related functions
YD Landry, M Denis, S Nandi, S Bell… - Journal of Biological …, 2006 - ASBMB
ATP-binding cassette transporter A1 (ABCA1) is known to mediate cholesterol efflux to lipid-
poor apolipoprotein AI. In addition, ABCA1 has been shown to influence functions of the
plasma membrane, such as endocytosis and phagocytosis. Here, we report that ABCA1
expression results in a significant redistribution of cholesterol and sphingomyelin from rafts
to non-rafts. Caveolin, a raft/caveolae marker also redistributes from punctate caveolae-like
structures to the general area of the plasma membrane upon ABCA1 expression …
poor apolipoprotein AI. In addition, ABCA1 has been shown to influence functions of the
plasma membrane, such as endocytosis and phagocytosis. Here, we report that ABCA1
expression results in a significant redistribution of cholesterol and sphingomyelin from rafts
to non-rafts. Caveolin, a raft/caveolae marker also redistributes from punctate caveolae-like
structures to the general area of the plasma membrane upon ABCA1 expression …