Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
P Birner, M Schindl, A Obermair, C Plank… - Cancer research, 2000 - AACR
P Birner, M Schindl, A Obermair, C Plank, G Breitenecker, G Oberhuber
Cancer research, 2000•AACRHypoxia-inducible factor 1α (HIF-1α) is a transcriptional factor that regulates genes involved
in response to hypoxia and promotes neoangiogenesis, which are considered essential for
tumor growth and progression. Using immunohistochemistry, we investigated the influence
of HIF-1α expression on prognosis in 91 patients with cervical cancer stage pT1b. In
univariate and multivariate analysis, patients with strong expression of HIF-1α had a
significantly shorter overall survival time (P= 0.0307, log-rank test) and disease-free survival …
in response to hypoxia and promotes neoangiogenesis, which are considered essential for
tumor growth and progression. Using immunohistochemistry, we investigated the influence
of HIF-1α expression on prognosis in 91 patients with cervical cancer stage pT1b. In
univariate and multivariate analysis, patients with strong expression of HIF-1α had a
significantly shorter overall survival time (P= 0.0307, log-rank test) and disease-free survival …
Abstract
Hypoxia-inducible factor 1α (HIF-1α) is a transcriptional factor that regulates genes involved in response to hypoxia and promotes neoangiogenesis, which are considered essential for tumor growth and progression. Using immunohistochemistry, we investigated the influence of HIF-1α expression on prognosis in 91 patients with cervical cancer stage pT1b. In univariate and multivariate analysis, patients with strong expression of HIF-1α had a significantly shorter overall survival time (P = 0.0307, log-rank test)and disease-free survival time (P < 0.0001, log-rank test) compared with those with moderate to absent HIF-1α expression. HIF-1α expression is a strong independent prognostic marker in early stage cervical cancer.
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