Interleukin 17–producing T helper cells in alloimmunity
FS Benghiat, LM Charbonnier, B Vokaer… - Transplantation …, 2009 - Elsevier
Interleukin (IL) 17 is a proinflammatory cytokine already known to play a defense role
against microbes and a pathogenic role in a number of autoimmune diseases. Although IL-
17 can be produced by a variety of cells including neutrophils, CD8+, NK, and gamma-delta
T cells, the concept of IL-17–secreting CD4+ T helper cells (Th17), distinct from Th1 and
Th2, recently emerged. Herein, we discuss arguments in favor of a Th17-mediated
alternative pathway of allograft rejection based on clinical and experimental observations …
against microbes and a pathogenic role in a number of autoimmune diseases. Although IL-
17 can be produced by a variety of cells including neutrophils, CD8+, NK, and gamma-delta
T cells, the concept of IL-17–secreting CD4+ T helper cells (Th17), distinct from Th1 and
Th2, recently emerged. Herein, we discuss arguments in favor of a Th17-mediated
alternative pathway of allograft rejection based on clinical and experimental observations …