Acetate and fluoroacetate as possible markers for glial metabolism in vivo
D Muir, S Berl, DD Clarke - Brain research, 1986 - Elsevier
D Muir, S Berl, DD Clarke
Brain research, 1986•ElsevierAbstract [3 H] Acetate has been shown by light autoradiographic methods to label the
neuropil but not the perikarya in brain and retina.[3 H] Fluoroacetate behaves similarly. The
study provides anatomical data which support the concept of metabolic compartmentation of
glutamic acid and associated metabolites previously derived from biochemical studies. It is
suggested that these may be markers of non-neuronal metabolism, probably mostly glial,
and may be used to develop procedures which will provide complementary data to that …
neuropil but not the perikarya in brain and retina.[3 H] Fluoroacetate behaves similarly. The
study provides anatomical data which support the concept of metabolic compartmentation of
glutamic acid and associated metabolites previously derived from biochemical studies. It is
suggested that these may be markers of non-neuronal metabolism, probably mostly glial,
and may be used to develop procedures which will provide complementary data to that …
Abstract
[3H]Acetate has been shown by light autoradiographic methods to label the neuropil but not the perikarya in brain and retina. [3H]Fluoroacetate behaves similarly. The study provides anatomical data which support the concept of metabolic compartmentation of glutamic acid and associated metabolites previously derived from biochemical studies. It is suggested that these may be markers of non-neuronal metabolism, probably mostly glial, and may be used to develop procedures which will provide complementary data to that obtained with 2-deoxyglucose on regional metabolism in brain.
Elsevier