[HTML][HTML] Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule …
AV Fonseca, D Freund, M Bornhäuser… - Journal of biological …, 2010 - ASBMB
Understanding the physiological migration of hematopoietic progenitors is important, not
only for basic stem cell research, but also in view of their therapeutic relevance. Here, we
investigated the role of the Rho kinase pathway in the morphology and migration of
hematopoietic progenitors using an ex vivo co-culture consisting of human primary CD34+
progenitors and mesenchymal stromal cells. The addition of the Rho kinase inhibitor Y-
27632 led to the abolishment of the uropod and microvillar-like structures of hematopoietic …
only for basic stem cell research, but also in view of their therapeutic relevance. Here, we
investigated the role of the Rho kinase pathway in the morphology and migration of
hematopoietic progenitors using an ex vivo co-culture consisting of human primary CD34+
progenitors and mesenchymal stromal cells. The addition of the Rho kinase inhibitor Y-
27632 led to the abolishment of the uropod and microvillar-like structures of hematopoietic …