[HTML][HTML] Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival
AC Shirali, M Look, W Du, E Kassis… - American Journal of …, 2011 - Elsevier
Conventional immunosuppressive drug delivery requires high systemic drug levels to
provide therapeutic benefit, but frequently results in toxic side effects. Novel drug delivery
methods, such as FDA-approved poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs),
are promising drug delivery platforms to reduce drug doses and minimize toxicity. Using
murine models of skin transplantation, we investigated whether PLGA NPs would effectively
deliver mycophenolic acid (MPA), a common clinical immunosuppressant, and avoid the …
provide therapeutic benefit, but frequently results in toxic side effects. Novel drug delivery
methods, such as FDA-approved poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs),
are promising drug delivery platforms to reduce drug doses and minimize toxicity. Using
murine models of skin transplantation, we investigated whether PLGA NPs would effectively
deliver mycophenolic acid (MPA), a common clinical immunosuppressant, and avoid the …