[HTML][HTML] Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors

BA Babbin, WY Lee, CA Parkos, LM Winfree… - Journal of Biological …, 2006 - ASBMB
Annexin 1 (AnxA1) is a multifunctional phospholipid-binding protein associated with the
development of metastasis in some invasive epithelial malignancies. However, the role of
AnxA1 in the migration/invasion of epithelial cells is not known. In this study, experiments
were performed to investigate the role of AnxA1 in the invasion of a model epithelial cell line,
SKCO-15, derived from colorectal adenocarcinoma. Small interfering RNA-mediated
knockdown of AnxA1 expression resulted in a significant reduction in invasion through …