Acute colitis produced by chemotactic peptides in rats and mice.
JF Chester, JS Ross, RA Malt… - The American journal of …, 1985 - ncbi.nlm.nih.gov
JF Chester, JS Ross, RA Malt, SA Weitzman
The American journal of pathology, 1985•ncbi.nlm.nih.govColonic inflammation was produced in rats and mice by peptides chemotactic for
polymorphonuclear leukocytes. Instillation of formylmethionyl-leucyl-phenylalanine (FMLP)
and formylnorleucyl-leucyl-phenylalanine (FNLP) into isolated segments of rat colon caused
marked mucosal edema and polymorphonuclear leukocyte infiltration within 2 hours. Higher
concentrations of FNLP caused ulceration and necrosis as well. Formylmethionine (FMet), a
compound with less chemotactic activity, caused much less inflammation. In mice, rectal …
polymorphonuclear leukocytes. Instillation of formylmethionyl-leucyl-phenylalanine (FMLP)
and formylnorleucyl-leucyl-phenylalanine (FNLP) into isolated segments of rat colon caused
marked mucosal edema and polymorphonuclear leukocyte infiltration within 2 hours. Higher
concentrations of FNLP caused ulceration and necrosis as well. Formylmethionine (FMet), a
compound with less chemotactic activity, caused much less inflammation. In mice, rectal …
Abstract
Colonic inflammation was produced in rats and mice by peptides chemotactic for polymorphonuclear leukocytes. Instillation of formylmethionyl-leucyl-phenylalanine (FMLP) and formylnorleucyl-leucyl-phenylalanine (FNLP) into isolated segments of rat colon caused marked mucosal edema and polymorphonuclear leukocyte infiltration within 2 hours. Higher concentrations of FNLP caused ulceration and necrosis as well. Formylmethionine (FMet), a compound with less chemotactic activity, caused much less inflammation. In mice, rectal instillation of FNLP caused dose-dependent acute mucosal inflammation which persisted for longer than 12 hours. Twice-weekly rectal instillation of FNLP provided a model of colitis based on neutrophil chemotaxis.
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