Leukocyte recruitment to sites of inflammation and infection is dependent on the presence of
a gradient of locally produced chemotactic factors. This review is focused on current
knowledge about the activation and regulation of chemoattractant receptors. Emphasis is
placed on the members of the N-formyl peptide receptor family, namely FPR (N-formyl
peptide receptor), FPRL1 (FPR like-1) and FPRL2 (FPR like-2), and the complement
fragment C5a receptors (C5aR and C5L2). Upon chemoattractant binding, the receptors …