Notch signalling during peripheral T-cell activation and differentiation
BA Osborne, LM Minter - Nature Reviews Immunology, 2007 - nature.com
BA Osborne, LM Minter
Nature Reviews Immunology, 2007•nature.comFor many years, researchers have focused on the contribution of Notch signalling to
lymphoid development. Only recently have investigators begun to ask what role, if any,
Notch has during the activation and differentiation of naive CD4+ T cells in the periphery. As
interest in this issue grows, it is becoming increasingly clear that the main role of Notch
signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells.
lymphoid development. Only recently have investigators begun to ask what role, if any,
Notch has during the activation and differentiation of naive CD4+ T cells in the periphery. As
interest in this issue grows, it is becoming increasingly clear that the main role of Notch
signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells.
Abstract
For many years, researchers have focused on the contribution of Notch signalling to lymphoid development. Only recently have investigators begun to ask what role, if any, Notch has during the activation and differentiation of naive CD4+ T cells in the periphery. As interest in this issue grows, it is becoming increasingly clear that the main role of Notch signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells.
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