Effects of long-term inhibition of neuronal nitric oxide synthase (NOS1) in uninephrectomized diabetic rats
R Komers, JN Lindsley, TT Oyama, S Anderson - Nitric Oxide, 2004 - Elsevier
Nitric oxide (NO) has been implicated in the pathogenesis of renal hemodynamic changes in
diabetes mellitus (DM). However, the role of NO in the pathophysiology of diabetic
nephropathy remains controversial. Renal hemodynamic changes in experimental DM can
be acutely normalized by selective inhibition of neuronal NO synthase (nNOS). This
observation suggests a nephroprotective potential of nNOS inhibition in DM. To explore this
issue we assessed the long-term effects (12 weeks) of selective nNOS inhibition with the …
diabetes mellitus (DM). However, the role of NO in the pathophysiology of diabetic
nephropathy remains controversial. Renal hemodynamic changes in experimental DM can
be acutely normalized by selective inhibition of neuronal NO synthase (nNOS). This
observation suggests a nephroprotective potential of nNOS inhibition in DM. To explore this
issue we assessed the long-term effects (12 weeks) of selective nNOS inhibition with the …