Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9

JM Rutkowski, M Moya, J Johannes, J Goldman… - Microvascular …, 2006 - Elsevier
Disturbances in the microcirculation can lead to secondary lymphedema, a common
pathological condition that, despite its frequency, still lacks a cure. Lymphedema is clinically
well described, but while the genetic underpinnings that cause lymphatic malformations and
primary lymphedema are being discovered, the pathophysiology and pathobiology of
secondary lymphedema remain poorly understood, partly due to the lack of well-described
experimental models. Here, we provide a detailed characterization of secondary …