[HTML][HTML] Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes
S Mitsutake, K Zama, H Yokota, T Yoshida… - Journal of Biological …, 2011 - ASBMB
Lipid microdomains or caveolae, small invaginations of plasma membrane, have emerged
as important elements for lipid uptake and glucose homeostasis. Sphingomyelin (SM) is one
of the major phospholipids of the lipid microdomains. In this study, we investigated the
physiological function of sphingomyelin synthase 2 (SMS2) using SMS2 knock-out mice,
and we found that SMS2 deficiency prevents high fat diet-induced obesity and insulin
resistance. Interestingly, in the liver of SMS2 knock-out mice, large and mature lipid droplets …
as important elements for lipid uptake and glucose homeostasis. Sphingomyelin (SM) is one
of the major phospholipids of the lipid microdomains. In this study, we investigated the
physiological function of sphingomyelin synthase 2 (SMS2) using SMS2 knock-out mice,
and we found that SMS2 deficiency prevents high fat diet-induced obesity and insulin
resistance. Interestingly, in the liver of SMS2 knock-out mice, large and mature lipid droplets …