[HTML][HTML] Transgenic reexpression of GLUT1 or GLUT2 in pancreatic β cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin …
B Thorens, MT Guillam, F Beermann, R Burcelin… - Journal of Biological …, 2000 - ASBMB
GLUT2-null mice are hyperglycemic, hypoinsulinemic, hyperglucagonemic, and glycosuric
and die within the first 3 weeks of life. Their endocrine pancreas shows a loss of first phase
glucose-stimulated insulin secretion (GSIS) and inverse α to β cell ratio. Here we show that
reexpression by transgenesis of either GLUT1 or GLUT2 in the pancreatic β cells of these
mice allowed mouse survival and breeding. The rescued mice had normal-fed glycemia but
fasted hypoglycemia, glycosuria, and an elevated glucagon to insulin ratio. Glucose …
and die within the first 3 weeks of life. Their endocrine pancreas shows a loss of first phase
glucose-stimulated insulin secretion (GSIS) and inverse α to β cell ratio. Here we show that
reexpression by transgenesis of either GLUT1 or GLUT2 in the pancreatic β cells of these
mice allowed mouse survival and breeding. The rescued mice had normal-fed glycemia but
fasted hypoglycemia, glycosuria, and an elevated glucagon to insulin ratio. Glucose …