[HTML][HTML] Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane
JG Donaldson - Journal of Biological Chemistry, 2003 - ASBMB
The ADP-ribosylation factors (Arfs) 1 are a family of Rasrelated, low molecular mass (20
kDa), GTP-binding proteins that are expressed in all eukaryotes. There are six mammalian
Arfs and many more Arf-like proteins. Like all GTPases, Arfs cycle between GDP-bound,
inactive and GTP-bound, active states. In the active state, Arfs interact with proteins and
other effector molecules to carry out their functions. Although Arf1 and its activities at the
Golgi complex have been extensively studied, Arf6 has been the subject of increased …
kDa), GTP-binding proteins that are expressed in all eukaryotes. There are six mammalian
Arfs and many more Arf-like proteins. Like all GTPases, Arfs cycle between GDP-bound,
inactive and GTP-bound, active states. In the active state, Arfs interact with proteins and
other effector molecules to carry out their functions. Although Arf1 and its activities at the
Golgi complex have been extensively studied, Arf6 has been the subject of increased …