[HTML][HTML] Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action
C Graveleau, VG Zaha, A Mohajer, RR Banerjee… - Journal of biological …, 2005 - ASBMB
The adipocytokine resistin impairs glucose tolerance and insulin sensitivity in rodents. Here,
we examined the effect of resistin on glucose uptake in isolated adult mouse
cardiomyocytes. Murine resistin reduced insulin-stimulated glucose uptake, establishing the
heart as a resistin target tissue. Notably, human resistin also impaired insulin action in
mouse cardiomyocytes, providing the first evidence that human and mouse resistin
homologs have similar functions. Resistin is a cysteinerich molecule that circulates as a …
we examined the effect of resistin on glucose uptake in isolated adult mouse
cardiomyocytes. Murine resistin reduced insulin-stimulated glucose uptake, establishing the
heart as a resistin target tissue. Notably, human resistin also impaired insulin action in
mouse cardiomyocytes, providing the first evidence that human and mouse resistin
homologs have similar functions. Resistin is a cysteinerich molecule that circulates as a …