[HTML][HTML] Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2
C Zitt, B Strauss, EC Schwarz, N Spaeth, G Rast… - Journal of Biological …, 2004 - ASBMB
Ca 2+ entry through store-operated Ca 2+ release-activated Ca 2+(CRAC) channels is
essential for T-cell activation and proliferation. Recently, it has been shown that 3, 5-
bistrifluoromethyl pyrazole (BTP) derivatives are specific inhibitors of Ca 2+-dependent
transcriptional activity in T-cells (Trevillyan, JM, Chiou, XG, Chen, YW, Ballaron, SJ, Sheets,
MP, Smith, ML, Wiedeman, PE, Warrior, U., Wilkins, J., Gubbins, EJ, Gagne, GD, Fagerland,
J., Carter, GW, Luly, JR, Mollison, KW, and Djuric, SW (2001) J. Biol. Chem. 276, 48118 …
essential for T-cell activation and proliferation. Recently, it has been shown that 3, 5-
bistrifluoromethyl pyrazole (BTP) derivatives are specific inhibitors of Ca 2+-dependent
transcriptional activity in T-cells (Trevillyan, JM, Chiou, XG, Chen, YW, Ballaron, SJ, Sheets,
MP, Smith, ML, Wiedeman, PE, Warrior, U., Wilkins, J., Gubbins, EJ, Gagne, GD, Fagerland,
J., Carter, GW, Luly, JR, Mollison, KW, and Djuric, SW (2001) J. Biol. Chem. 276, 48118 …