[HTML][HTML] Rho/Rho-associated kinase signal regulates myogenic differentiation via myocardin-related transcription factor-A/Smad-dependent transcription of the Id3 …
K Iwasaki, K Hayashi, T Fujioka, K Sobue - Journal of biological chemistry, 2008 - ASBMB
RhoA is known to be involved in myogenic differentiation, but whether it acts as a positive or
negative regulator is controversial. To resolve this issue, we investigated the differentiation
stage-specific roles of RhoA and its effector, Rho-associated kinase, using C2C12
myoblasts. We found that proliferating myoblasts show high levels of RhoA and serum-
response factor activities and strong expression of the downstream target of RhoA,
myocardin-related transcription factor-A (MRTF-A or MAL); these activities and expression …
negative regulator is controversial. To resolve this issue, we investigated the differentiation
stage-specific roles of RhoA and its effector, Rho-associated kinase, using C2C12
myoblasts. We found that proliferating myoblasts show high levels of RhoA and serum-
response factor activities and strong expression of the downstream target of RhoA,
myocardin-related transcription factor-A (MRTF-A or MAL); these activities and expression …