[HTML][HTML] Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor …
DH Lao, P Yusoff, S Chandramouli, RJ Philp… - Journal of biological …, 2007 - ASBMB
In the context of fibroblast growth factor (FGF) signaling, Sprouty2 (Spry2) is the most
profound inhibitor of the Ras/ERK pathway as compared with other Spry isoforms. An
exclusive, necessary, but cryptic PXXPXR motif in the C terminus of Spry2 is revealed upon
stimulation. The activation of Spry2 appears to be linked to sequences in the N-terminal half
of the protein and correlated with a bandshifting seen on SDS-PAGE. The band-shifting is
likely caused by changes in the phosphorylation status of key Ser and Thr residues following …
profound inhibitor of the Ras/ERK pathway as compared with other Spry isoforms. An
exclusive, necessary, but cryptic PXXPXR motif in the C terminus of Spry2 is revealed upon
stimulation. The activation of Spry2 appears to be linked to sequences in the N-terminal half
of the protein and correlated with a bandshifting seen on SDS-PAGE. The band-shifting is
likely caused by changes in the phosphorylation status of key Ser and Thr residues following …