Expression of SOX9 and SOX10 in Central Neuroepithelial Tumor: Hamburg, 07.04.2006
U Kordes, C Hagel - Journal of neuro-oncology, 2006 - Springer
U Kordes, C Hagel
Journal of neuro-oncology, 2006•SpringerThe SOX group E transcription factors play an integral role in the specification and
differentiation of astrocytes and oligodendrocytes. We have examined the pattern of
expression for SOX9 and SOX10 in primary brain tumors by immunohistochemistry.
Pediatric and adult high grade tumors display strong nuclear staining for both SOX9 and
SOX10 (astrocytic, oligodendroglial and primitive neuroectodermal tumors). In comparison
pediatric pilocytic astrocytoma express much less SOX9 and SOX10. Reactive astrogliosis is …
differentiation of astrocytes and oligodendrocytes. We have examined the pattern of
expression for SOX9 and SOX10 in primary brain tumors by immunohistochemistry.
Pediatric and adult high grade tumors display strong nuclear staining for both SOX9 and
SOX10 (astrocytic, oligodendroglial and primitive neuroectodermal tumors). In comparison
pediatric pilocytic astrocytoma express much less SOX9 and SOX10. Reactive astrogliosis is …
Abstract
The SOX group E transcription factors play an integral role in the specification and differentiation of astrocytes and oligodendrocytes. We have examined the pattern of expression for SOX9 and SOX10 in primary brain tumors by immunohistochemistry. Pediatric and adult high grade tumors display strong nuclear staining for both SOX9 and SOX10 (astrocytic, oligodendroglial and primitive neuroectodermal tumors). In comparison pediatric pilocytic astrocytoma express much less SOX9 and SOX10. Reactive astrogliosis is characterized by an increase of SOX9 only.
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