The biological action of androgenic male sex steroid hormones in prostate tissue is
mediated by the androgen receptor, a nuclear transcription factor. The transcriptional
program of androgenic signaling in the prostate consists of thousands of gene targets whose
products play a role in almost all cellular functions, including cellular proliferation, survival,
lipid metabolism, and differentiation. This review will provide a summary of the most recent
data regarding androgen-regulated target genes and modulation of androgen receptor …