[HTML][HTML] Functional importance of Dicer protein in the adaptive cellular response to hypoxia
JJD Ho, JL Metcalf, MS Yan, PJ Turgeon… - Journal of Biological …, 2012 - ASBMB
The processes by which cells sense and respond to ambient oxygen concentration are
fundamental to cell survival and function, and they commonly target gene regulatory events.
To date, however, little is known about the link between the microRNA pathway and hypoxia
signaling. Here, we show in vitro and in vivo that chronic hypoxia impairs Dicer (DICER1)
expression and activity, resulting in global consequences on microRNA biogenesis. We
show that von Hippel-Lindau-dependent down-regulation of Dicer is key to the expression …
fundamental to cell survival and function, and they commonly target gene regulatory events.
To date, however, little is known about the link between the microRNA pathway and hypoxia
signaling. Here, we show in vitro and in vivo that chronic hypoxia impairs Dicer (DICER1)
expression and activity, resulting in global consequences on microRNA biogenesis. We
show that von Hippel-Lindau-dependent down-regulation of Dicer is key to the expression …