The effects and potential mechanisms of the vascular endothelial cell (EC)-enriched
microRNA-15a (miR-15a) on angiogenesis remain unclear. Here, we show a novel finding
that EC-selective miR-15a transgenic overexpression leads to reduced blood vessel
formation and local blood flow perfusion in mouse hindlimbs at 1–3 weeks after hindlimb
ischemia. Mechanistically, gain-or loss-of-miR-15a function by lentiviral infection in ECs
significantly reduces or increases tube formation, cell migration, and cell differentiation …