[42] Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines
IA Trounce, YL Kim, AS Jun, DC Wallace - Methods in enzymology, 1996 - Elsevier
Publisher Summary This chapter discusses the methods of assessment of mitochondrial
oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial
cell lines. Investigation of oxidative phosphorylation (OX-PHOS) in mitochondrial diseases
has traditionally focused on the muscle biopsy. Skeletal muscle biopsy remains a valuable
resource for biochemical studies as it is an easily accessed tissue and milligram quantities
of mitochondria can be isolated for a wide range of OX-PHOS investigations. However, in …
oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial
cell lines. Investigation of oxidative phosphorylation (OX-PHOS) in mitochondrial diseases
has traditionally focused on the muscle biopsy. Skeletal muscle biopsy remains a valuable
resource for biochemical studies as it is an easily accessed tissue and milligram quantities
of mitochondria can be isolated for a wide range of OX-PHOS investigations. However, in …