[HTML][HTML] Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation
J Oh, AE Riek, S Weng, M Petty, D Kim… - Journal of Biological …, 2012 - ASBMB
Macrophages are essential in atherosclerosis progression, but regulation of the M1 versus
M2 phenotype and their role in cholesterol deposition are unclear. We demonstrate that
endoplasmic reticulum (ER) stress is a key regulator of macrophage differentiation and
cholesterol deposition. Macrophages from diabetic patients were classically or alternatively
stimulated and then exposed to oxidized LDL. Alternative stimulation into M2 macrophages
lead to increased foam cell formation by inducing scavenger receptor CD36 and SR-A1 …
M2 phenotype and their role in cholesterol deposition are unclear. We demonstrate that
endoplasmic reticulum (ER) stress is a key regulator of macrophage differentiation and
cholesterol deposition. Macrophages from diabetic patients were classically or alternatively
stimulated and then exposed to oxidized LDL. Alternative stimulation into M2 macrophages
lead to increased foam cell formation by inducing scavenger receptor CD36 and SR-A1 …