Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3–positive regulatory T cells
AH Massoud, J Guay, KH Shalaby, E Bjur… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Intravenous immunoglobulin (IVIG) is a frequently used disease-modifying
therapy for a large spectrum of autoimmune and inflammatory conditions, yet its
mechanisms of action are incompletely understood. Using a robust murine model of antigen-
driven allergic airways disease, we have demonstrated that IVIG markedly improves
ovalbumin (OVA)–induced airway hyperresponsiveness characterized by 4-to 6-fold
enhancement in regulatory T (Treg) cells in pulmonary and associated lymphoid tissues …
therapy for a large spectrum of autoimmune and inflammatory conditions, yet its
mechanisms of action are incompletely understood. Using a robust murine model of antigen-
driven allergic airways disease, we have demonstrated that IVIG markedly improves
ovalbumin (OVA)–induced airway hyperresponsiveness characterized by 4-to 6-fold
enhancement in regulatory T (Treg) cells in pulmonary and associated lymphoid tissues …