[HTML][HTML] MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation
DE McNulty, Z Li, CD White, DB Sacks… - Journal of biological …, 2011 - ASBMB
Cellular responses produced by EGF are mediated through the receptor (EGFR) and by
various enzymes and scaffolds. Recent studies document IQGAP1 as a scaffold for the
MAPK cascade, binding directly to B-Raf, MEK, and ERK and regulating their activation in
response to EGF. We previously showed that EGF is unable to activate B-Raf in cells lacking
IQGAP1. However, the mechanism by which IQGAP1 links B-Raf to EGFR was unknown.
Here we report that endogenous EGFR and IQGAP1 co-localize and co-immunoprecipitate …
various enzymes and scaffolds. Recent studies document IQGAP1 as a scaffold for the
MAPK cascade, binding directly to B-Raf, MEK, and ERK and regulating their activation in
response to EGF. We previously showed that EGF is unable to activate B-Raf in cells lacking
IQGAP1. However, the mechanism by which IQGAP1 links B-Raf to EGFR was unknown.
Here we report that endogenous EGFR and IQGAP1 co-localize and co-immunoprecipitate …