[HTML][HTML] IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells
L Jadeski, JM Mataraza, HW Jeong, Z Li… - Journal of biological …, 2008 - ASBMB
The scaffold protein IQGAP1 integrates signaling pathways and participates in diverse
cellular activities. IQGAP1 is overexpressed in a number of human solid neoplasms, but its
functional role in tumorigenesis has not been previously evaluated. Here we report that
IQGAP1 contributes to neoplastic transformation of human breast epithelial cells. The
amount of IQGAP1 in breast carcinoma is greater than that in normal tissue, with highly
metastatic breast epithelial cells expressing the highest levels. Overexpression of IQGAP1 …
cellular activities. IQGAP1 is overexpressed in a number of human solid neoplasms, but its
functional role in tumorigenesis has not been previously evaluated. Here we report that
IQGAP1 contributes to neoplastic transformation of human breast epithelial cells. The
amount of IQGAP1 in breast carcinoma is greater than that in normal tissue, with highly
metastatic breast epithelial cells expressing the highest levels. Overexpression of IQGAP1 …