Increased gene expression levels of collagen receptor integrins are associated with decreased survival parameters in patients with advanced melanoma
M Vuoristo, P Vihinen, T Vlaykova, C Nylund… - Melanoma …, 2007 - journals.lww.com
Expression of collagen receptor integrins α1β1 and α2β1 has been associated with
progression and metastatic potential of malignant melanoma. Integrin α2β1 was originally
characterized as a melanoma progression antigen. We have used real-time quantitative
PCR to study the mRNA expression levels of three collagen receptor integrin chains, that is
α1, α2 and α11 in metastases from 26 patients with melanoma. Interestingly, we find that
survival after initiation of chemoimmunotherapy was significantly decreased in all patients …
progression and metastatic potential of malignant melanoma. Integrin α2β1 was originally
characterized as a melanoma progression antigen. We have used real-time quantitative
PCR to study the mRNA expression levels of three collagen receptor integrin chains, that is
α1, α2 and α11 in metastases from 26 patients with melanoma. Interestingly, we find that
survival after initiation of chemoimmunotherapy was significantly decreased in all patients …