[HTML][HTML] Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
Sirtuins are evolutionarily conserved NAD+-dependent deacetylases and ADP-
ribosyltransferases involved in the regulation of cell division, apoptosis, DNA damage repair,
genomic silencing, and longevity. Recent studies have focused on identifying target
substrates for human sirtuin enzymatic activity, but little is known about processes that
directly regulate their function. Here, we demonstrate that SIRT2 is phosphorylated both in
vitro and in vivo on serine 368 by the cell-cycle regulator, cyclin-dependent kinase 1, and …
ribosyltransferases involved in the regulation of cell division, apoptosis, DNA damage repair,
genomic silencing, and longevity. Recent studies have focused on identifying target
substrates for human sirtuin enzymatic activity, but little is known about processes that
directly regulate their function. Here, we demonstrate that SIRT2 is phosphorylated both in
vitro and in vivo on serine 368 by the cell-cycle regulator, cyclin-dependent kinase 1, and …