Establishing and maintaining control of glycaemia is a key step in the reduction of diabetic
microvascular complications. By contrast, macrovascular disease which is the most
important complication and shortens the lives of many people with type 2 diabetes is not
reduced by glycaemic control alone. The landmark UK Prospective Diabetes Study (UKPDS)
showed that intensive glycaemic management with metformin significantly reduced the risk
of a range of debilitating and/or life-threatening macrovascular complications, compared …